干细胞治疗一直是高度关注的热点。在武汉已经完成了超过200例的干细胞治疗，干细胞治疗能够抑制免疫系统过度激活，通过改善微环境，促进内源性修复，抑制肺部进行研究的进展。那么干细胞究竟是不是智商税呢？ 第一个吃螃蟹的人可能会付出智商税，但换来的却是先行者的红利。与其 在键盘上调侃，不如退而结网，让自己成为一个有资格交税的人。
stem cell therapy has been a high priority. More than 200 stem cell therapy cases have been completed in Wuhan, and stem cell therapy has been able to inhibit the excessive activation of the immune system and, by improving the micro-environment, to promote endogenous restoration and to curb the progress of lung research.
都说人赚不到认知范围以外的钱，这可以成为一类人裹足不前的借口，也可以成为另外一类人不断突破自己认知的动力。 ?
"Strong" says that people don't earn money outside the realm of knowledge, which can be an excuse for a group of people not to move forward, or for another group to continue to break through their consciousness. ?
你觉得这样一顶纯稻草帽应该多少钱？
How much do you think this is supposed to be a pure straw hat?
如果是村口的大爷，八块八 ，他还觉得有点儿贵。如果是路易斯威登的拥趸，就算8200，他要把它收入囊中，LV这顶天价藏帽，又是掀起了关于富人智商税的讨论。大家直呼，我连交智商税的资格都没有了。
If it's the owner of the village, it's eight dollars and eight dollars, and he's a bit expensive. If it's Louis Vuitton, even if it's 8,200, he's going to put it in his bag, and LV's name is going to start a discussion about the rich's IQ tax. You can call it, I can't even pay the IQ tax.
不过买点LV不值一提，非富即贵的圈层花钱方式超出你我的想象。10万美金的人体冷冻，25万美金可以太空一日游、千万美金的末世堡垒。当然还有风靡富人圈的干细胞医疗，甚至大家组团去使用，或者当做礼物相互赠送，注射干细胞好像成了圈层的标配。
But buying a few LVs is worth nothing, and the non-rich or expensive circles are spending more than you think. 100,000 humans are frozen, 250,000 dollars can travel day by day in space, millions of dollars in the Fort of the Last World. And, of course, there's dry cell medicine in the rich world, even when you're in groups, or as gifts to each other,
曾经中国商人前往乌克兰打干细胞续命的新闻，让干细胞仓皇出圈儿。但是新冠期间，干细胞又在救治重症患者上大显神通，被科技部和多位院士实名带货。
Chinese businessmen used to go to Ukraine for news of stem cell renewals, to get the stem cells out of the circle. But during the new crown,
大家都知道，干细胞治疗一直是高度关注的热点。在武汉已经完成了超过200例的干细胞治疗，干细胞治疗能够抑制免疫系统过度激活，通过改善微环境，促进内源性修复，抑制肺部进行研究的进展。那么干细胞究竟是不是智商税呢？
As you know, stem-cell therapy has been a high-profile hotspot. More than 200 stem-cell therapy cases have been completed in Wuhan.
至少在部分人眼里，干细胞就是富人智商税代名词。为什么我们还原到普通人角度来看，原因有5条：
At least in the eyes of some people, stem cells are the term IQ tax for rich people.
第一个就是贵
The first one is Precious.
贵啊，就是原罪。输注一次干细胞，有的价格相当于一枚比特币，这样中产新贵们都不敢贸然消费升级。
It's expensive, it's the original sin. The price of a drop in stem cells is equivalent to a bitcoin, so that the new elites don't dare to increase their consumption.
第二个就是乱
The second is chaos.
几家都说自己是干细胞，价格可以差出一辆特斯拉，收费的方式也是花样百出。最邪乎的是用免费干细胞来吸引，但却收着天价的床位费。
Several of them say they're stem cells, and the price falls short of a Tesla, and the way they charge is a lot of money. The evil thing is to use free stem cells to attract them, but they charge a daily price for the bed.
第三个就是吹
The third one is blowing.
返老还童，药到病除，长生不老、百毒不侵等神乎其神的效果，脱口而出，可真要细究，他又含糊其辞，不专业程度令人发指。甚至某些医生连造血干细胞和间充质干细胞区别都分不清楚。
Back in the old age of the child, medicine to cure the disease, immortality, intoxication and the like of God's effects, it's true to speak out, he's vague and unprofessional. It's not even clear what the difference is between the blood stem cells and the inoculation stem cells of some doctors.
第四个杂
干细胞种类花样百出，甭管是乌克兰的胚胎干细胞，日本的自体干细胞，美国的脐血干细胞还是羊的、牛的，甚至是植物的，口服的、外敷的，都说自己背景多权威，效果最牛叉。 The variety of stem cells varies from embryonic stem cells in Ukraine to stem stem cells in Japan, cord stem cells in the United States, sheep, cattle, even plants, oral and external, all say that they are the most authoritative and effective. 最后就是黑！ {\bord0\shad0\alphaH3D}The last thing is black! 干细胞产品信息不透明，你不问他也绝对不说。组织捐赠者的健康状况，细胞制备的标准，细胞出厂检测数据、药监局核准资质等，一切都语言不详，留给你的唯一印象就是细胞数越多越好。 The information on stem cell products is not transparent, and he will never say 看了干细胞医疗的这五大罪状，你会不会想，果不其然，我就知道这是如假包换的智商税。 When you look at these five counts of stem cell medicine, do you think that, if not, I'll know it's a fake IQ tax. 但如果你真这么认为，不仅错过了干细胞，还把智商留在了只见树木的层面。为什么中、美、欧、日会把干细胞医疗作为国家级的战略? But if you really think so, not only did you miss stem cells, but you left IQ at the tree-only level. Why does China, America, Europe, Japan use stem cell medicine as a strategy at the national level? 首先，技术层面 First, at the technical level 自从1892年德国科学家bobbery and hacker 给干细胞取了名之后，在这129年间相继发现了造血、胚胎、间充质等多种干细胞，并人为创造了多能诱导干细胞，总共贡献了5位诺贝尔医学奖获得者。到2021年，文献库帕麦收入了干细胞相关文献，总共有45万多篇，nature 和cell这样的顶级期刊也都创立了与干细胞相关的子刊。可以这么说，干细胞的巨大医学潜力早就是学术共同体的普遍认知。 Since German scientists bobbery and hacker named stem cells in 1892, several stem cells, such as blood-making, embryos, intercharges, etc., have been discovered successively in 129 years, and man-made creation of multi-powered induction stem cells has contributed to a total of five Nobel Prize laureates. By 2021, Cooper's literature included stem cell-related literature, with more than 450,000 copies, and top periodicals like nature and cell creating sub-records related to stem cells. In this case, the huge medical potential of 其次，临床层面 根据clinical trials的记录，全球关于干细胞的临床研究共有8363项，其中美国独占鳌头，开展的项目有4130项。欧洲第二，中国及亚洲地区第三。干细胞覆盖临床适应症有2055种，包括但不限于阿尔兹海默症、抑郁症、白血病、黄斑病变、心肌梗塞、中风、1/2型糖尿病、衰老症和关节炎等等。 According to the records of clinical trials, there are 8363 clinical studies on stem cells worldwide, of which the United States is the sole leader with 4130 projects. Second, in Europe, China and the Asian region, there are three. 其中已经有数款干细胞药物已经通过审核上市，比如针对移植排异反应的prochymal 和temcell。针对白血病的hemacord等等。再次，市场层面预计到2025年，全球干细胞市场规模约2700亿美金，复合增长率13.8%。 Several of these stem-cell drugs have been placed on the market, such as prochymal and tellell for transplants. Hemacord for leukaemia, etc. The market level is expected to be about $270 billion by 2025 in global stem-cell markets and 13.8 per cent in composite growth rates. 目前，干细胞产业链已经逐步形成，从上游干细胞采集与储存到中游的干细胞增殖与产品研发，再到下游的临床应用都初具规模。并且已经造就了caladrius Biosciences、Sangamo、 Therapeutics等十家NASDAQ上市公司。 The stem cell industry chain has now evolved, from upstream stem cell collection and storage to midstream stem cell enrichment and product development to downstream clinical applications of initial scale. Ten NASDAQ companies, including Caladrius Biosciences, Sangamo, Therapeutics, etc., have been created. 到这里你也许会问，既然干细胞有坚实的基本面,那为何又会乱象重生呢？因为有三重矛盾: And here you might ask, "Why is it that stem cells have solid fundamentals?" Because of the triple contradiction: 1 、宏观发展VS微观决策 1, macro-development VS micro-decision-making 作为一个普通患者，没人在意宏观的基本面，我们所关心的无非是干细胞有什么用，安全吗？效果怎样，贵不贵？通常做法就是三步：网络搜索、朋友咨询、沟通还价。但凡有朋友推荐，加上销售，火候拿捏到位。就心一横做上了。如果有效，当然是暗自庆幸，但凡与预期不符，那肯定是痛骂自己是被割了智商税的韭菜。 As a normal patient, no one cares about the fundamentals of the macro, and what is our concern about stem cells, and what is safe? How is 2 、干细胞治疗机制VS传统药物机制 小分子药物的靶向治疗是针对某个蛋白受体或基因的精准打击。而干细胞的作用机制呢？是治疗范式上的改变，它更贴合系统生物学或者传统中医的理论，把人体作为一个系统来看待。通过对免疫系统及血液系统的再生修复来消除病症，因此在近千种疾病上都显示的治疗潜力，所以也难怪干细胞被误解为能够包治百病的“假药”。 The target of a small molecular drug is a precise attack on a protein receptor or gene. And 3、 个体化治疗VS医疗成本 3, personalized treatment VS medical costs 想便宜肯定得标准化和规模化生产，但是干细胞作为个体化治疗代表，细胞药品化的科研投入巨大，细胞制备过程复杂，审核标准严苛。过程坎坷，说白了就是需要的人才多，烧钱快，时间长，困难大。而且医疗服务高度定制化，价格贵也是无可奈何。所以目前来说，干细胞医疗确实只有金字塔尖的人才能够承担。 In order to be cheap, it would have to be standardized and scaled up, but stem cells, as a proxy for individualized therapy, have a huge investment in 而之所以有以上三重矛盾，问题的根源，还是干细胞医疗技术仍是前沿科学，技术本身无论有多大的潜力，落地为实在的医疗服务，不可能一蹴而就。医学的发展大体就是个盲人摸象的拼图，这个过程会因为新技术的出现而加速，但却不能逾越。作为一个普通患者，感受到的只是干细胞医疗的冰山一角。虽然他现在有些扑朔迷离，但是冰山一旦浮出水面，势必会成为带来无限生机的新大陆。 This three-fold contradiction, the root cause of the problem, is that stem-cell medical technology is still the cutting edge of science, and that technology itself, no matter what its potential, can’t be a real medical service. The development of medicine is largely a puzzle of the image of the blind, but it can’t be overtaken by the emergence of new technologies. As a common patient, it is only the tip of an iceberg of stem-cell medicine. 什么是干细胞治疗？ What's stem cell therapy? 干细胞治疗是利用干细胞或其衍生物来促进病变、功能障碍或受损组织的修复。随着技术的发展，科研人员能够在实验室中培养干细胞，这些干细胞被用来分化成特定类型的细胞，例如心肌细胞、血细胞或神经细胞。这些细胞有助于修复相应的有缺陷的组织或器官。 The stem cell treatment is the use of stem cells or their derivatives to promote the repair of disease, functional disorders or damaged tissues. With the development of technology, scientists are able to cultivate stem cells in laboratories, which are used to divide into specific types of cells, such as myocardial, blood or neurological cells. These cells help to repair the corresponding defective tissues or organs. 值得一提的是，存在于人体几乎所有组织中的间充质干细胞，除了具有自我更新及分化潜能外，还具有独特的免疫调节功能，并且可定向迁移至损伤组织部位，在多种疾病的治疗中具有十分广阔的临床应用前景。当前，所有在研干细胞疗法中，基于间充质干细胞的疗法占主流。 It is worth mentioning that 间充质干细胞是最近几年国内外干细胞治疗研究最多，发展速度最快的品种，它能够分化形成骨、软骨、脂肪、神经、肌肉等多种组织细胞，因此正在被应用于治疗多种疾病的研究中。 Inter-filled stem cells, which have been the most studied in recent years at home and abroad, have developed the fastest-growing varieties of stem cell therapy capable of splitting into multiple tissue cells, such as bone, cartilage, fat, nerves and muscles, and are therefore being applied in research on the treatment of multiple diseases. 同时，间充质干细胞被认为是修复和再造人体受损组织或器官的好材料。间充质干细胞最早在骨髓中发现，之后，被发现在婴儿出生后的胎盘、脐带、脂肪组织中均有存在。间充质干细胞的应用研究最早是用于骨和软骨的修复，现在间充质干细胞治疗研究已经扩展到脑中风、脑瘫、急性心梗和慢性缺血性心脏病、肝脏疾病，以及牙科，角膜、血液疾病等等方面。 At the same time, is considered to be a good material for repairing and reconstructing damaged tissues or organs of the human body . is the first to be found in bone marrow and then found in post-natal placenta, umbilical cords, adipose tissues. is the first to be used in bone and cartilage restoration, and research into intersult stem stem therapy has now been extended to the areas of brain stroke, cerebral palsy, acute heart disease and chronic ischaemic heart disease, liver disease, dental, cornea, blood disease, etc. 干细胞治疗其他疾病临床应用 内分泌系统类疾病：二型糖尿病 （99.58%）、更年期综合症 （96%） Endocrine system diseases: Diabetes II (99.58 per cent), menopause syndrome (96 per cent) 免疫系统类疾病：关节炎 （80%）、关节退行性变 （80%）、骨髓炎 （80%）、系统性红斑狼疮 （80%）、癌症化疗后恢复免疫功能 （90%） 消化系统类疾病： Diseases of the digestive system: 慢性萎缩性胃炎 （97%）、乙型和丙型肝炎 （95%）、酒精性肝病 （93%）、肝硬化（95%）、肝硬化腹水 （85%）、肝纤维化 （85%）、脂肪肝 （85%）、克罗恩病 （90%） Chronic atrophy of stomachitis (97 per cent), hepatitis B and C (95 per cent), alcoholic hepatitis (93 per cent), liver cirrhosis (95 per cent), liver cirrhosis (85 per cent), liver fibrosis (85 per cent), fat liver (85 per cent), Crohn disease (90 per cent) 呼吸系统类疾病： Respiratory Diseases: 慢性阻塞性肺疾病 （80%） Chronic obstructive lung disease (80%) 泌尿系统类疾病： 前列腺疾病 （90%）、肾功能衰竭 （90%） Prostate diseases (90%), kidney failure (90%) 循环系统类疾病： circulatory diseases: 心肌（95%）、心脏衰竭 （85%）、动脉硬化（90%）、脑梗塞（85%）、下肢严重缺血 （95%） Heart muscle (95 per cent), heart failure (85 per cent), arterial sclerosis (90 per cent), brain infarction (85 per cent), severe hypothermia in the lower limbs (95 per cent) 神经系统类疾病： 中风 （80%）、帕金森 （80%）、阿尔茨海默氏病 （85%）、脑膜炎及其后遗症（75%） stroke (80 per cent), Parkinson (80 per cent), Alzheimer's disease (85 per cent), meningitis and its aftermath (75 per cent) 生殖系统类疾病： Diseases of the reproductive system: 不孕不育（90%）、性功能障碍（98%） Infertility (90%), sexual impairment (98%) ?一句话总结，干细胞医疗充满潜力，未知与挑战。 ? strange? summing up, stem cell medicine is full of potential, unknown and challenging. 它虽然仍是高高在上的奢侈医疗，但正渐渐走向大众。干细胞是再生医学、个体化医疗和细胞疗法的三位一体，肯定不是智商税。 It's still a luxury, but it's moving towards the general public. The stem cells are a triad of regenerative medicine, individualized medicine and cell therapy, and certainly not an IQ tax. 最后咱再说说智商税，谁会热衷于鉴定智商税呢？还不是我们这些普通而自信的大多数。成功者之所以成功，他们看清了人生不是有限的零和博弈，而是一场无限游戏。当我们为躲过一次商税而洋洋得意的时候，却可能错失了让我们阶级越迁的两样武器：好奇心和勇气。 Finally, let us say that IQ tax, and who is interested in judging IQ tax? Not just the average and confident majority of us. The success of `strong' shows that life is not a limited zero-sum game, but an infinite game . /Strong > may miss two weapons to keep our class moving: curiosity and courage. 第一个吃螃蟹的人可能会付出智商税，但换来的却是先行者的红利。与其在键盘上调侃，不如退而结网，让自己成为一个有资格交税的人。都说人赚不到认知范围以外的钱，这可以成为一类人裹足不前的借口，也可以成为另外一类人不断突破自己认知的动力。 The first one to eat crabs may pay an IQ tax, but in return it will be the dividend of the pioneer . Instead of playing on the keyboard, it will be better to get off the grid and make yourself eligible to pay taxes. All say that people don't earn money beyond the realm of knowledge, which can be an excuse for a group of people to stay out of it, or an incentive for others to break through their own perception.
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